FOR ACADEMIC NON-COMMERCIAL RESEARCH PURPOSES ONLY
Download the License
Please download each file individually. The Manual, Resources, and MD5 checksums are available without registration and can be downloaded through the web browser or using command-line download managers (e.g., using wget).
NeoDisc software requires email registration. After registering, you will receive an email with a unique download link. Please ensure that you open the link in the same browser used for registration and that cookies are enabled on the website.
Version 1.7.0 – bugfix 2
Bug Fixes:
• Improvement in the -cleandnafq and -cleanrnafq outputs: support for a wider range of FASTQ sequence identifier formats.
• Addition of light and full modes to -cleandnafq and -cleanrnafq:
• light mode reformats FASTQ read identifiers into a format compatible with GATK and Picard tools.
• full mode performs the same reformatting and also deduplicates reads.
• Fixed a bug affecting the combination of MS-identified peptides when only HLA-I or HLA-II injections were measured, but predicted binders existed for both HLA-I and HLA-II.
Version 1.7.0 – bugfix 1
To enhance the download experience, the resources have been separated from the container. As a result, the installation process has changed slightly, as reflected in the updated Manual. Additionally, a few bugs have been fixed in the Software and Resources.
Bug Fixes:
• Fixed issue with running MS analysis using DIA only.
• Resolved problem when running MS analysis with only HLA-I or HLA-II alleles.
• Corrected underestimation of mutational load when using gencode_v43 as the capture kit.
• Added –no-home and –cleanenv options to the Singularity command to prevent loading environment variables in the container.
• Various minor bug fixes.
Version 1.7.0
First release of NeoDisc, as published in:
A comprehensive proteogenomic pipeline for neoantigen discovery to advance personalized cancer immunotherapy
Huber F, et al. Nature Biotechnology, 2024, 10.1038/s41587-024-02420-y